Alcohol dehydrogenase (ADH) and cytochrome P450 2E1 (CYP2E1) each catalyze ethanol oxidation, producing acetaldehyde. This aldehyde enhances Egr-1 gene transcription by activating the Egr-1 promoter, thereby increasing the levels of Egr-1 mRNA and, subsequently, nuclear Egr-1 protein. It is believed that nuclear Egr-1 protein regulates transcription of SREBP-1c and tumor necrosis factor (TNF) genes to… Continue reading Alcoholic hepatitis Diagnosis and treatment
